CABOZANTINIB IS EFFECTIVE IN A SUBSET OF XENOGRAFT GBM TUMORS AND AFFECTS MULTIPLE SIGNALING PATHWAYS

BACKGROUND: (blind field). METHODS: Neurospheres enriched in CSCs were cultured from resected GBM tumors. Sensitivity to cabozantinib was determined in vitro. Cells were treated (IC40) in triplicate, and cell lysates were analyzed by reverse phase protein microarrays (RPPAs). GBM CSCs were implanted...

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Autori principali: Mikkelsen, Tom, deCarvalho, Ana C., Arnold, Kimberly, Mueller, Claudius, Petricoin, Emanuel F, Poisson, Laila M., Irtenkauf, Susan, Hasselbach, Laura
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144606/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.58
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