CABOZANTINIB IS EFFECTIVE IN A SUBSET OF XENOGRAFT GBM TUMORS AND AFFECTS MULTIPLE SIGNALING PATHWAYS

BACKGROUND: (blind field). METHODS: Neurospheres enriched in CSCs were cultured from resected GBM tumors. Sensitivity to cabozantinib was determined in vitro. Cells were treated (IC40) in triplicate, and cell lysates were analyzed by reverse phase protein microarrays (RPPAs). GBM CSCs were implanted...

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Hlavní autoři: Mikkelsen, Tom, deCarvalho, Ana C., Arnold, Kimberly, Mueller, Claudius, Petricoin, Emanuel F, Poisson, Laila M., Irtenkauf, Susan, Hasselbach, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144606/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.58
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