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GENE-23. DISCORDANT INHERITANCE OF CHROMOSOMAL AND EXTRACHROMOSOMAL DNA ELEMENTS CONTRIBUTE TO DYNAMIC DISEASE EVOLUTION IN GLIOBLASTOMA
Somatic evolution in glioblastoma (GBM) is a dynamic process favoring clonal architecture beneficial to tumor growth. Oncogene amplification in extra-chromosomal DNA (ecDNA) is frequent in GBMs. In contrast to somatic chromosomal abnormalities, ecDNA amplification results in highly variable copy num...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692909/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.397 |
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