Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

To understand how genomic heterogeneity of glioblastoma contributes to the poor response to therapy characteristic of this disease, we performed DNA and RNA sequencing on GBM tumor samples and the neurospheres and orthotopic xenograft models derived from them. We used the resulting data set to show...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: deCarvalho, Ana C., Kim, Hoon, Poisson, Laila M., Winn, Mary E., Mueller, Claudius, Cherba, David, Koeman, Julie, Seth, Sahil, Protopopov, Alexei, Felicella, Michelle, Zheng, Siyuan, Multani, Asha, Jiang, Yongying, Zhang, Jianhua, Nam, Do-Hyun, Petricoin, Emanuel F., Chin, Lynda, Mikkelsen, Tom, Verhaak, Roel G.W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934307/
https://ncbi.nlm.nih.gov/pubmed/29686388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0105-0
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