The interaction between σ(70) and the β-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation

The σ-subunit of bacterial RNA polymerase (RNAP) is required for promoter-specific transcription initiation. This function depends on specific intersubunit interactions that occur when σ associates with the RNAP core enzyme to form RNAP holoenzyme. Among these interactions, that between conserved re...

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Bibliographic Details
Main Authors: Nickels, Bryce E., Garrity, Sean J., Mekler, Vladimir, Minakhin, Leonid, Severinov, Konstantin, Ebright, Richard H., Hochschild, Ann
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC555512/
https://ncbi.nlm.nih.gov/pubmed/15761057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409850102
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