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Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins

Local conformational fluctuations in proteins can affect the coupling between ligand binding and global structural transitions. This finding was established by monitoring quantitatively how the population distribution in the ensemble of microstates of staphylococcal nuclease was affected by proton b...

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Detalhes bibliográficos
Main Authors: Whitten, Steven T., García-Moreno E., Bertrand, Hilser, Vincent J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555489/
https://ncbi.nlm.nih.gov/pubmed/15767576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407499102
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