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Exploring the impact of polyproline II (P(II)) conformational bias on the binding of peptides to the SEM-5 SH3 domain

The left-handed polyproline II helical structure (P(II)) is observed to be a dominant conformation in the disordered states of protein and small polypeptide chains, even when no prolines are present in the sequence. Recently, in work by Ferreon and Hilser, the energetics associated with Ala and Gly...

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Detalhes bibliográficos
Main Authors: Whitten, Steven T., Yang, Huan-Wang, Fox, Robert O., Hilser, Vincent J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441998/
https://ncbi.nlm.nih.gov/pubmed/18577755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.033647.107
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