טוען...

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

Elucidating the complex interplay between protein structure and dynamics is a prerequisite to an understanding of both function and adaptation in proteins. Unfortunately, it has been difficult to experimentally decouple these effects because it is challenging to rationally design mutations that will...

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מידע ביבליוגרפי
Main Authors: Schrank, Travis P., Bolen, D. Wayne, Hilser, Vincent J.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761315/
https://ncbi.nlm.nih.gov/pubmed/19805185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906510106
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