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From cyclohydrolase to oxidoreductase: Discovery of nitrile reductase activity in a common fold

The enzyme YkvM from Bacillus subtilis was identified previously along with three other enzymes (YkvJKL) in a bioinformatics search for enzymes involved in the biosynthesis of queuosine, a 7-deazaguanine modified nucleoside found in tRNA(GUN) of Bacteria and Eukarya. Genetic analysis of ykvJKLM muta...

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Detalhes bibliográficos
Main Authors: Van Lanen, Steven G., Reader, John S., Swairjo, Manal A., de Crécy-Lagard, Valérie, Lee, Bobby, Iwata-Reuyl, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555470/
https://ncbi.nlm.nih.gov/pubmed/15767583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408056102
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