Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB

GTP cyclohydrolase I (GCYH-I) is an essential Zn(2+)-dependent enzyme that catalyzes the first step of the de novo folate biosynthetic pathway in bacteria and plants, the 7-deazapurine biosynthetic pathway in Bacteria and Archaea, and the biopterin pathway in mammals. We recently reported the discov...

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Detalhes bibliográficos
Main Authors: Sankaran, Banumathi, Bonnett, Shilah A., Shah, Kinjal, Gabriel, Scott, Reddy, Robert, Schimmel, Paul, Rodionov, Dmitry A., de Crécy-Lagard, Valérie, Helmann, John D., Iwata-Reuyl, Dirk, Swairjo, Manal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Enzymes and Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772490/
https://ncbi.nlm.nih.gov/pubmed/19767425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00287-09
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