Induction of retinoid X receptor activity and consequent up-regulation of p21(WAF1/CIP1) by indenoisoquinolines in MCF7 cells

Retinoid X receptor (RXR) has been targeted for the chemoprevention and treatment of cancer. To discover potential agents acting through RXRs, we utilized an RXR response element-luciferase reporter gene assay. Following extensive screening, 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-inden...

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Pubblicato in:Cancer Prev Res (Phila)
Autori principali: Park, Eun-Jung, Kondratyuk, Tamara P., Morrell, Andrew, Kiselev, Evgeny, Conda-Sheridan, Martin, Cushman, Mark, Ahn, Soyoun, Choi, Yongsoo, White, Jerry J., van Breemen, Richard B., Pezzuto, John M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554444/
https://ncbi.nlm.nih.gov/pubmed/21464033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0004
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