Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution Give Aptamers against Glypican-3-Overexpressing Tumor Cells

Laboratory in vitro evolution (LIVE) might deliver DNA aptamers that bind proteins expressed on the surface of cells. Here, we use cell engineering to place on the surface of a liver cell line glypican 3 (GPC3), a possible marker for liver cancer diagnostics and theranostics. Libraries were then bui...

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Udgivet i:Angew Chem Int Ed Engl
Main Authors: Zhang, Liqin, Yang, Zunyi, Le Trinh, Thu, Teng, I-Ting, Wang, Sai, Bradley, Kevin M, Hoshika, Shuichi, Wu, Qunfeng, Cansiz, Sena, Rowold, Diane J, McLendon, Christopher, Kim, Myong-Sang, Wu, Yuan, Cui, Cheng, Liu, Yuan, Hou, Weijia, Stewart, Kimberly, Wan, Shuo, Liu, Chen, Benner, Steven A., Tan, Weihong
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554412/
https://ncbi.nlm.nih.gov/pubmed/27601357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201605058
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