A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy

AS1411 (previously known as AGRO100) is a 26 nucleotide guanine-rich DNA aptamer which forms a guanine quadruplex structure. AS1411 has shown promising utility as a treatment for cancers in Phase I and Phase II clinical trials without causing major side-effects. AS1411 inhibits tumor cell growth by...

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Publicat a:PLoS One
Autors principals: Trinh, Thu Le, Zhu, Guizhi, Xiao, Xilin, Puszyk, William, Sefah, Kwame, Wu, Qunfeng, Tan, Weihong, Liu, Chen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629891/
https://ncbi.nlm.nih.gov/pubmed/26523833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136673
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