Enhanced Targeted Gene Transduction: AAV2 Vectors Conjugated to Multiple Aptamers via Reducible Disulfide Linkages

Enhanced targeted gene transduction by AAV2 vectors is achieved by linking the vector to multiple sgc8 aptamers, which are selective for cell membrane protein PTK7. Aptamer molecules are conjugated to multiple sites on a DNA dendrimer (G-sgc8), which is then linked to AAV2 via a dithiobis(succinimid...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Wu, Yuan, Zhang, Liqin, Cui, Cheng, Cansiz, Sena, Liang, Hao, Wu, Cuichen, Teng, I-Ting, Chen, Weijun, Liu, Yuan, Hou, Weijia, Zhang, Xiaobing, Tan, Weihong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877795/
https://ncbi.nlm.nih.gov/pubmed/29256602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08518
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