Enhanced Targeted Gene Transduction: AAV2 Vectors Conjugated to Multiple Aptamers via Reducible Disulfide Linkages

Enhanced targeted gene transduction by AAV2 vectors is achieved by linking the vector to multiple sgc8 aptamers, which are selective for cell membrane protein PTK7. Aptamer molecules are conjugated to multiple sites on a DNA dendrimer (G-sgc8), which is then linked to AAV2 via a dithiobis(succinimid...

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Udgivet i:J Am Chem Soc
Main Authors: Wu, Yuan, Zhang, Liqin, Cui, Cheng, Cansiz, Sena, Liang, Hao, Wu, Cuichen, Teng, I-Ting, Chen, Weijun, Liu, Yuan, Hou, Weijia, Zhang, Xiaobing, Tan, Weihong
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877795/
https://ncbi.nlm.nih.gov/pubmed/29256602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08518
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