Enhanced Targeted Gene Transduction: AAV2 Vectors Conjugated to Multiple Aptamers via Reducible Disulfide Linkages

Enhanced targeted gene transduction by AAV2 vectors is achieved by linking the vector to multiple sgc8 aptamers, which are selective for cell membrane protein PTK7. Aptamer molecules are conjugated to multiple sites on a DNA dendrimer (G-sgc8), which is then linked to AAV2 via a dithiobis(succinimid...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Am Chem Soc
मुख्य लेखकों: Wu, Yuan, Zhang, Liqin, Cui, Cheng, Cansiz, Sena, Liang, Hao, Wu, Cuichen, Teng, I-Ting, Chen, Weijun, Liu, Yuan, Hou, Weijia, Zhang, Xiaobing, Tan, Weihong
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877795/
https://ncbi.nlm.nih.gov/pubmed/29256602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08518
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