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An Aptamer-Nanotrain Assembled from 6-Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells

Expanding the number of nucleotides in DNA increases the information density of functional DNA molecules, creating nanoassemblies that cannot be invaded by natural DNA/RNA in complex biological systems. Here, we show how 6-letter GACTZP DNA contributes this property in two parts of a nanoassembly: (...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhang, Liqin, Wang, Sai, Yang, Zunyi, Hoshika, Shuichi, Xie, Sitao, Li, Jin, Chen, Xigao, Wan, Shuo, Li, Long, Benner, Steven, Tan, Weihong
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157901/
https://ncbi.nlm.nih.gov/pubmed/31650689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201909691
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