Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

Prion diseases in humans and animals are invariably fatal. Prions are composed of a disease-causing isoform (PrP(Sc)) of the normal host prion protein (PrP(C)) and replicate by stimulating the conversion of PrP(C) into nascent PrP(Sc). We report here that tricyclic derivatives of acridine and phenot...

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Bibliographic Details
Main Authors: Korth, Carsten, May, Barnaby C. H., Cohen, Fred E., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC55539/
https://ncbi.nlm.nih.gov/pubmed/11504948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161274798
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