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Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

Prion diseases in humans and animals are invariably fatal. Prions are composed of a disease-causing isoform (PrP(Sc)) of the normal host prion protein (PrP(C)) and replicate by stimulating the conversion of PrP(C) into nascent PrP(Sc). We report here that tricyclic derivatives of acridine and phenot...

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Detalles Bibliográficos
Main Authors: Korth, Carsten, May, Barnaby C. H., Cohen, Fred E., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC55539/
https://ncbi.nlm.nih.gov/pubmed/11504948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161274798
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