Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

Prion diseases in humans and animals are invariably fatal. Prions are composed of a disease-causing isoform (PrP(Sc)) of the normal host prion protein (PrP(C)) and replicate by stimulating the conversion of PrP(C) into nascent PrP(Sc). We report here that tricyclic derivatives of acridine and phenot...

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Detaylı Bibliyografya
Asıl Yazarlar: Korth, Carsten, May, Barnaby C. H., Cohen, Fred E., Prusiner, Stanley B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC55539/
https://ncbi.nlm.nih.gov/pubmed/11504948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161274798
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