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Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease
Prion diseases in humans and animals are invariably fatal. Prions are composed of a disease-causing isoform (PrP(Sc)) of the normal host prion protein (PrP(C)) and replicate by stimulating the conversion of PrP(C) into nascent PrP(Sc). We report here that tricyclic derivatives of acridine and phenot...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55539/ https://ncbi.nlm.nih.gov/pubmed/11504948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161274798 |
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