Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Several studies showed that neutralizing anti–factor VIII (anti-fVIII) antibodies (inhibitors) in patients with acquired hemophilia A (AHA) and congenital hemophilia A (HA) are primarily directed to the A2 and C2 domains. In this study, the frequency and epitope specificity of anti-C1 antibodies wer...

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Veröffentlicht in:Blood
Hauptverfasser: Kahle, Joerg, Orlowski, Aleksander, Stichel, Diana, Healey, John F., Parker, Ernest T., Jacquemin, Marc, Krause, Manuela, Tiede, Andreas, Schwabe, Dirk, Lollar, Pete, Königs, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553573/
https://ncbi.nlm.nih.gov/pubmed/28507083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-751347
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