Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump

Antibiotic resistance is a major threat to human welfare. Inhibitors of multidrug efflux pumps (EPIs) are promising alternative therapeutics that could revive activities of antibiotics and reduce bacterial virulence. Identification of new druggable sites for inhibition is critical for the developmen...

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Gepubliceerd in:ACS Infect Dis
Hoofdauteurs: Abdali, Narges, Parks, Jerry M., Haynes, Keith M., Chaney, Julie L., Green, Adam T., Wolloscheck, David, Walker, John K., Rybenkov, Valentin V., Baudry, Jerome, Smith, Jeremy C., Zgurskaya, Helen I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553321/
https://ncbi.nlm.nih.gov/pubmed/27768847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00167
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