Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells

Recent evidence indicates that inhibition of HIV-1 integrase (IN) binding to the viral RNA genome by allosteric integrase inhibitors (ALLINIs) or through mutations within IN yields aberrant particles in which the viral ribonucleoprotein complexes (vRNPs) are eccentrically localized outside the capsi...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Madison, Michaela K., Lawson, Dana Q., Elliott, Jennifer, Ozantürk, Ayşe Naz, Koneru, Pratibha C., Townsend, Dana, Errando, Manel, Kvaratskhelia, Mamuka, Kutluay, Sebla B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553177/
https://ncbi.nlm.nih.gov/pubmed/28615207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00821-17
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