Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells

Recent evidence indicates that inhibition of HIV-1 integrase (IN) binding to the viral RNA genome by allosteric integrase inhibitors (ALLINIs) or through mutations within IN yields aberrant particles in which the viral ribonucleoprotein complexes (vRNPs) are eccentrically localized outside the capsi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Madison, Michaela K., Lawson, Dana Q., Elliott, Jennifer, Ozantürk, Ayşe Naz, Koneru, Pratibha C., Townsend, Dana, Errando, Manel, Kvaratskhelia, Mamuka, Kutluay, Sebla B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2017
Pynciau:
Virus-Cell Interactions
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553177/
https://ncbi.nlm.nih.gov/pubmed/28615207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00821-17
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