An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors

[Image: see text] Allosteric HIV-1 integrase inhibitors (ALLINIs) are a new class of potential antiretroviral therapies with a unique mechanism of action and drug resistance profile. To further extend this class of inhibitors via a scaffold hopping approach, we have synthesized a series of analogues...

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Опубликовано в: :ACS Med Chem Lett
Главные авторы: Wilson, Tyler A., Koneru, Pratibha C., Rebensburg, Stephanie V., Lindenberger, Jared J., Kobe, Matthew J., Cockroft, Nicholas T., Adu-Ampratwum, Daniel, Larue, Ross C., Kvaratskhelia, Mamuka, Fuchs, James R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2019
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378678/
https://ncbi.nlm.nih.gov/pubmed/30783506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00633
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