Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the...

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Published in:Sci Rep
Main Authors: Antila, Hanna, Ryazantseva, Maria, Popova, Dina, Sipilä, Pia, Guirado, Ramon, Kohtala, Samuel, Yalcin, Ipek, Lindholm, Jesse, Vesa, Liisa, Sato, Vinicius, Cordeira, Joshua, Autio, Henri, Kislin, Mikhail, Rios, Maribel, Joca, Sâmia, Casarotto, Plinio, Khiroug, Leonard, Lauri, Sari, Taira, Tomi, Castrén, Eero, Rantamäki, Tomi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552878/
https://ncbi.nlm.nih.gov/pubmed/28798343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08166-9
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