Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain

Wnt signaling plays an important role in governing cell fate decisions. Coiled-coil-DIX1 (Ccd1), Dishevelled (Dvl), and Axin are signaling proteins that regulate the canonical pathway by controlling the stability of a key signal transducer β-catenin. These proteins contain the DIX domain with a ubiq...

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發表在:Sci Rep
Main Authors: Terawaki, Shin-ichi, Fujita, Shohei, Katsutani, Takuya, Shiomi, Kensuke, Keino-Masu, Kazuko, Masu, Masayuki, Wakamatsu, Kaori, Shibata, Naoki, Higuchi, Yoshiki
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552852/
https://ncbi.nlm.nih.gov/pubmed/28798413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08019-5
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