Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

Human mtDNA contains three promoters, suggesting a need for differential expression of the mitochondrial genome. Studies of mitochondrial transcription have used a reductionist approach, perhaps masking differential regulation. Here we evaluate transcription from light-strand (LSP) and heavy-strand...

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Veröffentlicht in:eLife
Hauptverfasser: Uchida, Akira, Murugesapillai, Divakaran, Kastner, Markus, Wang, Yao, Lodeiro, Maria F, Prabhakar, Shaan, Oliver, Guinevere V, Arnold, Jamie J, Maher, L James, Williams, Mark C, Cameron, Craig E
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552277/
https://ncbi.nlm.nih.gov/pubmed/28745586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27283
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