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Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro

Cell-based studies support the existence of two promoters on the heavy strand of mtDNA: heavy-strand promoter 1 (HSP1) and HSP2. However, transcription from HSP2 has been reported only once in a cell-free system, and never when recombinant proteins have been used. Here, we document transcription fro...

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Autors principals: Lodeiro, Maria F., Uchida, Akira, Bestwick, Megan, Moustafa, Ibrahim M., Arnold, Jamie J., Shadel, Gerald S., Cameron, Craig E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340051/
https://ncbi.nlm.nih.gov/pubmed/22493245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118710109
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