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Double-Strand Breaks of Mouse Muscle mtDNA Promote Large-Deletions Similar to Multiple mtDNA Deletions in Humans
Mitochondrial DNA (mtDNA) deletions are a common cause of mitochondrial disorders and have been found to accumulate during normal aging. Despite the fact that hundreds of deletions have been characterized at the molecular level, their mechanisms of genesis are unknown. We tested the effect of double...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1242110/ https://ncbi.nlm.nih.gov/pubmed/15703189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddi082 |
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