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The islet-resident macrophage is in an inflammatory state and senses microbial products in blood
We examined the transcriptional profiles of macrophages that reside in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD), NOD.Rag1(−/−), and B6.g7 mice. Islet macrophages expressed an activation signature with high expression of Tnf, Il1b, and MHC-II at both the transcript and protein le...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551574/ https://ncbi.nlm.nih.gov/pubmed/28630088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170074 |
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