Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveol...

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Vydáno v:J Exp Med
Hlavní autoři: Misharin, Alexander V., Morales-Nebreda, Luisa, Reyfman, Paul A., Cuda, Carla M., Walter, James M., McQuattie-Pimentel, Alexandra C., Chen, Ching-I, Anekalla, Kishore R., Joshi, Nikita, Williams, Kinola J.N., Abdala-Valencia, Hiam, Yacoub, Tyrone J., Chi, Monica, Chiu, Stephen, Gonzalez-Gonzalez, Francisco J., Gates, Khalilah, Lam, Anna P., Nicholson, Trevor T., Homan, Philip J., Soberanes, Saul, Dominguez, Salina, Morgan, Vince K., Saber, Rana, Shaffer, Alexander, Hinchcliff, Monique, Marshall, Stacy A., Bharat, Ankit, Berdnikovs, Sergejs, Bhorade, Sangeeta M., Bartom, Elizabeth T., Morimoto, Richard I., Balch, William E., Sznajder, Jacob I., Chandel, Navdeep S., Mutlu, Gökhan M., Jain, Manu, Gottardi, Cara J., Singer, Benjamin D., Ridge, Karen M., Bagheri, Neda, Shilatifard, Ali, Budinger, G.R. Scott, Perlman, Harris
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551573/
https://ncbi.nlm.nih.gov/pubmed/28694385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162152
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