Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveol...

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Detalhes bibliográficos
Publicado no:J Exp Med
Principais autores: Misharin, Alexander V., Morales-Nebreda, Luisa, Reyfman, Paul A., Cuda, Carla M., Walter, James M., McQuattie-Pimentel, Alexandra C., Chen, Ching-I, Anekalla, Kishore R., Joshi, Nikita, Williams, Kinola J.N., Abdala-Valencia, Hiam, Yacoub, Tyrone J., Chi, Monica, Chiu, Stephen, Gonzalez-Gonzalez, Francisco J., Gates, Khalilah, Lam, Anna P., Nicholson, Trevor T., Homan, Philip J., Soberanes, Saul, Dominguez, Salina, Morgan, Vince K., Saber, Rana, Shaffer, Alexander, Hinchcliff, Monique, Marshall, Stacy A., Bharat, Ankit, Berdnikovs, Sergejs, Bhorade, Sangeeta M., Bartom, Elizabeth T., Morimoto, Richard I., Balch, William E., Sznajder, Jacob I., Chandel, Navdeep S., Mutlu, Gökhan M., Jain, Manu, Gottardi, Cara J., Singer, Benjamin D., Ridge, Karen M., Bagheri, Neda, Shilatifard, Ali, Budinger, G.R. Scott, Perlman, Harris
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551573/
https://ncbi.nlm.nih.gov/pubmed/28694385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162152
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