Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells

Immunotherapy using checkpoint-blocking antibodies against targets such as CTLA-4 and PD-1 can cure melanoma and non–small cell lung cancer in a subset of patients. The presence of CD8 T cells in the tumor correlates with improved survival. We show that immuno–positron emission tomography (immuno-PE...

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Publicado en:J Exp Med
Main Authors: Rashidian, Mohammad, Ingram, Jessica R., Dougan, Michael, Dongre, Anushka, Whang, Katherine A., LeGall, Camille, Cragnolini, Juan J., Bierie, Brian, Gostissa, Monica, Gorman, James, Grotenbreg, Gijsbert M., Bhan, Atul, Weinberg, Robert A., Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2017
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551571/
https://ncbi.nlm.nih.gov/pubmed/28666979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161950
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