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Structure-based identification of inhibitors targeting obstruction of the HIVgp41 N-Heptad repeat trimer
The viral protein HIVgp41 is an attractive and validated drug target that proceeds through a sequence of conformational changes crucial for membrane fusion, which facilitates viral entry. Prior work has identified inhibitors that interfere with the formation of a required six-helix bundle, composed...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551449/ https://ncbi.nlm.nih.gov/pubmed/28558972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.05.020 |
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