Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In both primary murine cortical neurons and HT22 hippocampal neuro...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Song, Dan-Dan, Zhang, Tong-Tong, Chen, Jia-Li, Xia, Yun-Fei, Qin, Zheng-Hong, Waeber, Christian, Sheng, Rui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550846/
https://ncbi.nlm.nih.gov/pubmed/28682313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.289
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