BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models

Several cancer cell types, including chronic lymphocytic leukemia (CLL) and diffuse large B-cell lymphoma (DLBCL) upregulate antiapoptotic Bcl-2 to cope with oncogenic stress. BH3 mimetics targeting Bcl-2’s hydrophobic cleft have been developed, including venetoclax as a promising anticancer precisi...

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保存先:
書誌詳細
出版年:Cell Death Dis
主要な著者: Vervloessem, Tamara, Sasi, Binu K., Xerxa, Elena, Karamanou, Spyridoula, Kale, Justin, La Rovere, Rita M., Chakraborty, Supriya, Sneyers, Flore, Vogler, Meike, Economou, Anastassios, Laurenti, Luca, Andrews, David W., Efremov, Dimitar G., Bultynck, Geert
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498462/
https://ncbi.nlm.nih.gov/pubmed/32943617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02944-6
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