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BH4 domain of Bcl-2 as a novel target for cancer therapy
Overexpression of B cell lymphoma 2 (Bcl-2) proteins is associated with therapy resistance in various human cancers. Traditional approaches target the Bcl-2 homology (BH)3 domain of Bcl-2; however, the BH4 domain represents a superior therapeutic target in light of its unique structure and crucial i...
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| Publicado no: | Drug Discov Today |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882289/ https://ncbi.nlm.nih.gov/pubmed/26631752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2015.11.008 |
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