Small Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified a small molecule Bcl2-BH4 domain-antagonist (BDA-366) that binds BH4 with high affinity and selectivity. BDA-366-Bcl2 binding induces conformational change in Bcl2 that a...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Han, Bingshe, Park, Dongkyoo, Li, Rui, Xie, Maohua, Owonikoko, Taofeek K., Zhang, Guojing, Sica, Gabriel L., Ding, Chunyong, Zhou, Jia, Magis, Andrew T., Chen, Zhuo G., Shin, Dong M., Ramalingam, Suresh S., Khuri, Fadlo R., Curran, Walter J., Deng, Xingming
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470473/
https://ncbi.nlm.nih.gov/pubmed/26004684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.04.010
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