Small Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified a small molecule Bcl2-BH4 domain-antagonist (BDA-366) that binds BH4 with high affinity and selectivity. BDA-366-Bcl2 binding induces conformational change in Bcl2 that a...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cancer Cell
Huvudupphovsmän: Han, Bingshe, Park, Dongkyoo, Li, Rui, Xie, Maohua, Owonikoko, Taofeek K., Zhang, Guojing, Sica, Gabriel L., Ding, Chunyong, Zhou, Jia, Magis, Andrew T., Chen, Zhuo G., Shin, Dong M., Ramalingam, Suresh S., Khuri, Fadlo R., Curran, Walter J., Deng, Xingming
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470473/
https://ncbi.nlm.nih.gov/pubmed/26004684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.04.010
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk