Small Molecule Bax Agonists for Cancer Therapy

Bax, a central death regulator, is required at the decisional stage of apoptosis. We recently identified serine 184 (S184) of Bax as a critical functional switch controlling its proapoptotic activity. Here, we employed the structural pocket around S184 as a docking site to screen the NCI library of...

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Detaylı Bibliyografya
Asıl Yazarlar: Xin, Meiguo, Li, Rui, Xie, Maohua, Park, Dongkyoo, Owonikoko, Taofeek K., Sica, Gabriel L., Corsino, Patrick E., Zhou, Jia, Ding, Chunyong, White, Mark A., Magis, Andrew T., Ramalingam, Suresh S., Curran, Walter J., Khuri, Fadlo R., Deng, Xingming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172359/
https://ncbi.nlm.nih.gov/pubmed/25230299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5935
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