Small Molecule Bax Agonists for Cancer Therapy

Bax, a central death regulator, is required at the decisional stage of apoptosis. We recently identified serine 184 (S184) of Bax as a critical functional switch controlling its proapoptotic activity. Here, we employed the structural pocket around S184 as a docking site to screen the NCI library of...

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Detalhes bibliográficos
Main Authors: Xin, Meiguo, Li, Rui, Xie, Maohua, Park, Dongkyoo, Owonikoko, Taofeek K., Sica, Gabriel L., Corsino, Patrick E., Zhou, Jia, Ding, Chunyong, White, Mark A., Magis, Andrew T., Ramalingam, Suresh S., Curran, Walter J., Khuri, Fadlo R., Deng, Xingming
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172359/
https://ncbi.nlm.nih.gov/pubmed/25230299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5935
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