Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. T315I Bcr-Abl is the most notorious point mutation to elicit acquired resistance to imatinib (IM), leading to poor prognosis. Therefore, it is urgent to search for additional approaches and targeting strateg...

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Publicado en:Cell Death Dis
Autores principales: Lan, Xiaoying, Zhao, Chong, Chen, Xin, Zhang, Peiquan, Zang, Dan, Wu, Jinjie, Chen, Jinghong, Long, Huidan, Yang, Li, Huang, Hongbiao, Wang, Xuejun, Shi, Xianping, Liu, Jinbao
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550844/
https://ncbi.nlm.nih.gov/pubmed/28682311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.284
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