A STING agonist given with OX40 receptor and PD-L1 modulators primes immunity and reduces tumor growth in tolerized mice

STING signaling induces interferon-β (IFNβ) production by intratumoral dendritic cells (DCs), driving T-cell priming and recruitment into the tumor microenvironment (TME). We examined to what extent pre-existing antigen tolerance influenced the efficacy of in situ delivery of a potent STING-activati...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Foote, Jeremy B., Kok, Marleen, Leatherman, James M., Armstrong, Todd D., Marcinkowski, Bridget C., Ojalvo, Laureen S., Kanne, David B., Jaffee, Elizabeth M., Dubensky, Thomas W., Emens, Leisha A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550830/
https://ncbi.nlm.nih.gov/pubmed/28483787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0284
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