TDP-43 stabilises the processing intermediates of mitochondrial transcripts

The 43-kDa trans-activating response region DNA-binding protein 43 (TDP-43) is a product of a causative gene for amyotrophic lateral sclerosis (ALS). Despite of accumulating evidence that mitochondrial dysfunction underlies the pathogenesis of TDP-43–related ALS, the roles of wild-type TDP-43 in mit...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Izumikawa, Keiichi, Nobe, Yuko, Yoshikawa, Harunori, Ishikawa, Hideaki, Miura, Yutaka, Nakayama, Hiroshi, Nonaka, Takashi, Hasegawa, Masato, Egawa, Naohiro, Inoue, Haruhisa, Nishikawa, Kouki, Yamano, Koji, Simpson, Richard J., Taoka, Masato, Yamauchi, Yoshio, Isobe, Toshiaki, Takahashi, Nobuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550480/
https://ncbi.nlm.nih.gov/pubmed/28794432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06953-y
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