TDP-43 regulates site-specific 2′-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs

TDP-43 regulates cellular levels of Cajal bodies (CBs) that provide platforms for the assembly and RNA modifications of small nuclear ribonucleoproteins (snRNPs) involved in pre-mRNA splicing. Alterations in these snRNPs may be linked to pathogenesis of amyotrophic lateral sclerosis. However, specif...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Izumikawa, Keiichi, Nobe, Yuko, Ishikawa, Hideaki, Yamauchi, Yoshio, Taoka, Masato, Sato, Ko, Nakayama, Hiroshi, Simpson, Richard J, Isobe, Toshiaki, Takahashi, Nobuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412121/
https://ncbi.nlm.nih.gov/pubmed/30759234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz086
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