Downregulation of LGR5 Expression Inhibits Cardiomyocyte Differentiation and Potentiates Endothelial Differentiation from Human Pluripotent Stem Cells

Understanding molecules involved in differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes and endothelial cells is important in advancing hPSCs for cell therapy and drug testing. Here, we report that LGR5, a leucine-rich repeat-containing G-protein-coupled receptor, plays a cri...

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Bibliografske podrobnosti
izdano v:Stem Cell Reports
Main Authors: Jha, Rajneesh, Singh, Monalisa, Wu, Qingling, Gentillon, Cinsley, Preininger, Marcela K., Xu, Chunhui
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550222/
https://ncbi.nlm.nih.gov/pubmed/28793247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.07.006
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