Downregulation of LGR5 Expression Inhibits Cardiomyocyte Differentiation and Potentiates Endothelial Differentiation from Human Pluripotent Stem Cells

Understanding molecules involved in differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes and endothelial cells is important in advancing hPSCs for cell therapy and drug testing. Here, we report that LGR5, a leucine-rich repeat-containing G-protein-coupled receptor, plays a cri...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Jha, Rajneesh, Singh, Monalisa, Wu, Qingling, Gentillon, Cinsley, Preininger, Marcela K., Xu, Chunhui
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550222/
https://ncbi.nlm.nih.gov/pubmed/28793247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.07.006
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