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Downregulation of LGR5 Expression Inhibits Cardiomyocyte Differentiation and Potentiates Endothelial Differentiation from Human Pluripotent Stem Cells

Understanding molecules involved in differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes and endothelial cells is important in advancing hPSCs for cell therapy and drug testing. Here, we report that LGR5, a leucine-rich repeat-containing G-protein-coupled receptor, plays a cri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Jha, Rajneesh, Singh, Monalisa, Wu, Qingling, Gentillon, Cinsley, Preininger, Marcela K., Xu, Chunhui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550222/
https://ncbi.nlm.nih.gov/pubmed/28793247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.07.006
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