Downregulation of LGR5 Expression Inhibits Cardiomyocyte Differentiation and Potentiates Endothelial Differentiation from Human Pluripotent Stem Cells

Understanding molecules involved in differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes and endothelial cells is important in advancing hPSCs for cell therapy and drug testing. Here, we report that LGR5, a leucine-rich repeat-containing G-protein-coupled receptor, plays a cri...

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Dades bibliogràfiques
Publicat a:Stem Cell Reports
Autors principals: Jha, Rajneesh, Singh, Monalisa, Wu, Qingling, Gentillon, Cinsley, Preininger, Marcela K., Xu, Chunhui
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550222/
https://ncbi.nlm.nih.gov/pubmed/28793247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.07.006
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