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Normalizing single-cell RNA sequencing data: Challenges and opportunities

Single-cell transcriptomics is becoming an important component of the molecular biologist’s toolkit. A critical step when analyzing this type of data is normalization. However, normalization is typically performed using methods developed for bulk RNA sequencing or even microarray data, whose suitabi...

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Bibliographic Details
Published in:Nat Methods
Main Authors: Vallejos, Catalina A., Risso, Davide, Scialdone, Antonio, Dudoit, Sandrine, Marioni, John C.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549838/
https://ncbi.nlm.nih.gov/pubmed/28504683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4292
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