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BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

Mutational inactivation of BRCA1 confers a cumulative lifetime risk of breast and ovarian cancers. However, the underlying basis for the tissue-restricted tumor-suppressive properties of BRCA1 remains poorly defined. Here we show that BRCA1 mediates ligand-independent transcriptional repression of t...

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Detalhes bibliográficos
Main Authors: Zheng, Lei, Annab, Lois A., Afshari, Cynthia A., Lee, Wen-Hwa, Boyer, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC55496/
https://ncbi.nlm.nih.gov/pubmed/11493692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171174298
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