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SIRT1 Represses Estrogen-signaling, Ligand-Independent ERα-mediated Transcription, and Cell Proliferation in Estrogen-Responsive Breast Cells
In prostate and breast cancer, the androgen and estrogen receptors mediate induction of androgen- and estrogen-responsive genes respectively, and stimulate cell proliferation in response to the binding of their cognate steroid hormones. Sirtuin 1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3852670/ https://ncbi.nlm.nih.gov/pubmed/23169992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-12-0102 |
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