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Evolution of new regulatory functions on biophysically realistic fitness landscapes

Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isola...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Friedlander, Tamar, Prizak, Roshan, Barton, Nicholas H., Tkačik, Gašper
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548793/
https://ncbi.nlm.nih.gov/pubmed/28790313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00238-8
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